2-Chloromandelic Acid is a crucial compound in pharmaceuticals, identified by CAS number 10421-85-9. It is known by various synonyms, including o-chloromandelic acid. Its molecular formula is C8H7ClO3, with a molecular weight of 186.59 g/mol.
This compound appears as a white to yellowish crystalline solid, with a melting point of 90-93°C and a boiling point of approximately 266.91°C. The flash point is 165.7°C, indicating its ignition temperature in air. It has a density of about 1.3245 g/cm³.
For optimal storage, keep it in a dark, dry place at room temperature. This ensures its stability and efficacy.
2-Chloromandelic Acid serves primarily as a pharmaceutical intermediate, particularly in synthesizing Clopidogrel, a key medication for preventing blood clots. Its stability and reactivity make it valuable in organic synthesis and the development of new drugs, significantly advancing healthcare.
o-Chloromandelic Acid (alias: o-Chloromandelic Acid, CAS No.: 10421-85-9) is a highly practical fine chemical raw material focusing on the fields of pharmaceutical chemistry and organic synthesis. Relying on its clear molecular structure, stable chemical properties and flexible application scenarios, it serves as a key auxiliary material in industrial production and scientific research, providing a reliable material foundation for downstream synthesis processes.
In terms of appearance, o-Chloromandelic Acid presents as a uniform white crystalline powder with no obvious odor. Its fine particle size is compatible with conventional chemical feeding operations, facilitating accurate weighing and mixing. Its chemical properties are clearly controllable, with a molecular formula of C₈H₇ClO₃, a molecular weight of 186.592, and an exact mass of 186.008377. Its molecular structure contains a hydroxyl group (-OH), a carboxyl group (-COOH) and an ortho-chlorine-substituted benzene ring simultaneously. This structure of "dual functional groups + substituted aromatic ring" not only endows it with reactivity to participate in various organic reactions, but also ensures structural specificity in specific synthesis pathways, providing sufficient reaction sites for subsequent functional derivation.
1. Outstanding Chemical Stability: Under storage and usage conditions that strictly comply with specifications, the product is not prone to decomposition, oxidation or deterioration. It can maintain stable core chemical properties for a long time, effectively reducing material loss during production and lowering the risk of synthesis failure caused by unstable raw materials. It is particularly suitable for pharmaceutical enterprises requiring long-term batch production.
2. Strong Adaptability of Physical Properties: The density is approximately 1.5±0.1 g/cm³, which is in line with the handling habits of conventional solid chemical raw materials. The boiling point is stably maintained at 350.3±27.0℃ (under 760 mmHg), and the flash point is as high as 165.7±23.7℃. The high flash point greatly reduces fire hazards during normal-temperature operation and storage, improving production safety. Although there are literature differences in melting point between 80-85℃ and 90-93℃, it can be adapted by slightly adjusting process parameters in practical application without affecting the overall reaction effect.
3. Significant Potential for Chiral Development: The molecular structure contains 1 uncertain atomic stereocenter. Relevant studies have confirmed that chiral resolution can be achieved by forming salt crystals with (R)-(+)-N-benzyl-1-phenylethylamine. This provides possibilities for developing optically active derivatives and expanding chiral drug synthesis scenarios, and its application space in the high-end pharmaceutical field can be further explored in the future.
4. Simple Storage Conditions: Only "sealed, cool and dry, away from light" conditions are required for long-term storage. No special temperature control or inert gas protection is needed, which reduces the investment in storage equipment and management costs, enabling small and medium-sized enterprises to easily achieve compliant storage.
As a key raw material for pharmaceutical synthesis, o-Chloromandelic Acid can participate in the construction of molecular structures of drugs with specific physiological activities. The chlorine substituent in its molecule can enhance the binding ability between the drug and the target protein, while the hydroxyl and carboxyl groups can connect active groups through reactions such as esterification and amidation. At present, it has been widely used in the synthesis of some antibacterial, anti-inflammatory and metabolic regulatory drugs, helping to improve the targeting and efficacy stability of drugs. It is an important supporting material for the R&D and production of pharmaceutical enterprises.
In the fields of laboratory research and industrial organic synthesis, this product can be used as a basic functional reagent to participate in various reactions such as esterification, acylation and aromatic substitution. For example, in the synthesis of complex aromatic carboxylic acid derivatives and functionalized benzene compounds, it can be used as a starting material or intermediate carrier to simplify the synthesis pathway and shorten the reaction cycle. At the same time, its stable chemical properties also make it an ideal test material in small-batch customized synthesis and new reaction process exploration, adapting to the diverse needs of scientific research institutions and fine chemical enterprises.
o-Chloromandelic Acid has significant transportation advantages, which greatly reduce the threshold and cost of the logistics link:
1. Non-hazardous Nature: The Dangerous Goods Transport Code is "NONH for all modes of transport", meaning it is not classified as a dangerous good in all transport modes (road, sea, air). No special dangerous goods transport permit is required, and enterprises can choose conventional logistics channels, greatly shortening the transport preparation cycle.
2. Packaging and Protection: It is recommended to use cardboard drums lined with polyethylene film or sealed aluminum foil bags for packaging. This can not only prevent dust leakage caused by transportation vibration, but also isolate moisture and light, meeting the product storage requirements. The product name, CAS No., storage precautions and other information should be clearly marked on the outer packaging to facilitate identification and management in the logistics link.
3. Convenient Declaration: During customs declaration, only basic elements such as "product name, component content and purpose" need to be provided. No additional complex dangerous goods inspection reports are required, which complies with international trade and domestic customs supervision regulations, reduces the risk of declaration errors, and ensures efficient customs clearance of goods.
1. What is 2-chloromandelic acid?
2-Chloromandelic acid is an important organic compound that is primarily used as a pharmaceutical intermediate.
2. What are the main advantages of 2-chloromandelic acid?
These advantages include wide application, low production cost, and minimal impact on the environment.
3. Which industries use 2-chloromandelic acid?
It is widely used in the pharmaceutical, cosmetic, and food industries.
4. What is the use of 2-chloromandelic acid in medicine?
It is a key intermediate in the synthesis of drugs such as clopidogrel, which prevents blood clots.
5. What are the storage conditions for 2-chloromandelic acid?
Store 2-chloromandelic acid in a dark, dry place at room temperature to maintain its stability.
2-Chloromandelic Acid is a crucial compound in pharmaceuticals, identified by CAS number 10421-85-9. It is known by various synonyms, including o-chloromandelic acid. Its molecular formula is C8H7ClO3, with a molecular weight of 186.59 g/mol.
This compound appears as a white to yellowish crystalline solid, with a melting point of 90-93°C and a boiling point of approximately 266.91°C. The flash point is 165.7°C, indicating its ignition temperature in air. It has a density of about 1.3245 g/cm³.
For optimal storage, keep it in a dark, dry place at room temperature. This ensures its stability and efficacy.
2-Chloromandelic Acid serves primarily as a pharmaceutical intermediate, particularly in synthesizing Clopidogrel, a key medication for preventing blood clots. Its stability and reactivity make it valuable in organic synthesis and the development of new drugs, significantly advancing healthcare.
o-Chloromandelic Acid (alias: o-Chloromandelic Acid, CAS No.: 10421-85-9) is a highly practical fine chemical raw material focusing on the fields of pharmaceutical chemistry and organic synthesis. Relying on its clear molecular structure, stable chemical properties and flexible application scenarios, it serves as a key auxiliary material in industrial production and scientific research, providing a reliable material foundation for downstream synthesis processes.
In terms of appearance, o-Chloromandelic Acid presents as a uniform white crystalline powder with no obvious odor. Its fine particle size is compatible with conventional chemical feeding operations, facilitating accurate weighing and mixing. Its chemical properties are clearly controllable, with a molecular formula of C₈H₇ClO₃, a molecular weight of 186.592, and an exact mass of 186.008377. Its molecular structure contains a hydroxyl group (-OH), a carboxyl group (-COOH) and an ortho-chlorine-substituted benzene ring simultaneously. This structure of "dual functional groups + substituted aromatic ring" not only endows it with reactivity to participate in various organic reactions, but also ensures structural specificity in specific synthesis pathways, providing sufficient reaction sites for subsequent functional derivation.
1. Outstanding Chemical Stability: Under storage and usage conditions that strictly comply with specifications, the product is not prone to decomposition, oxidation or deterioration. It can maintain stable core chemical properties for a long time, effectively reducing material loss during production and lowering the risk of synthesis failure caused by unstable raw materials. It is particularly suitable for pharmaceutical enterprises requiring long-term batch production.
2. Strong Adaptability of Physical Properties: The density is approximately 1.5±0.1 g/cm³, which is in line with the handling habits of conventional solid chemical raw materials. The boiling point is stably maintained at 350.3±27.0℃ (under 760 mmHg), and the flash point is as high as 165.7±23.7℃. The high flash point greatly reduces fire hazards during normal-temperature operation and storage, improving production safety. Although there are literature differences in melting point between 80-85℃ and 90-93℃, it can be adapted by slightly adjusting process parameters in practical application without affecting the overall reaction effect.
3. Significant Potential for Chiral Development: The molecular structure contains 1 uncertain atomic stereocenter. Relevant studies have confirmed that chiral resolution can be achieved by forming salt crystals with (R)-(+)-N-benzyl-1-phenylethylamine. This provides possibilities for developing optically active derivatives and expanding chiral drug synthesis scenarios, and its application space in the high-end pharmaceutical field can be further explored in the future.
4. Simple Storage Conditions: Only "sealed, cool and dry, away from light" conditions are required for long-term storage. No special temperature control or inert gas protection is needed, which reduces the investment in storage equipment and management costs, enabling small and medium-sized enterprises to easily achieve compliant storage.
As a key raw material for pharmaceutical synthesis, o-Chloromandelic Acid can participate in the construction of molecular structures of drugs with specific physiological activities. The chlorine substituent in its molecule can enhance the binding ability between the drug and the target protein, while the hydroxyl and carboxyl groups can connect active groups through reactions such as esterification and amidation. At present, it has been widely used in the synthesis of some antibacterial, anti-inflammatory and metabolic regulatory drugs, helping to improve the targeting and efficacy stability of drugs. It is an important supporting material for the R&D and production of pharmaceutical enterprises.
In the fields of laboratory research and industrial organic synthesis, this product can be used as a basic functional reagent to participate in various reactions such as esterification, acylation and aromatic substitution. For example, in the synthesis of complex aromatic carboxylic acid derivatives and functionalized benzene compounds, it can be used as a starting material or intermediate carrier to simplify the synthesis pathway and shorten the reaction cycle. At the same time, its stable chemical properties also make it an ideal test material in small-batch customized synthesis and new reaction process exploration, adapting to the diverse needs of scientific research institutions and fine chemical enterprises.
o-Chloromandelic Acid has significant transportation advantages, which greatly reduce the threshold and cost of the logistics link:
1. Non-hazardous Nature: The Dangerous Goods Transport Code is "NONH for all modes of transport", meaning it is not classified as a dangerous good in all transport modes (road, sea, air). No special dangerous goods transport permit is required, and enterprises can choose conventional logistics channels, greatly shortening the transport preparation cycle.
2. Packaging and Protection: It is recommended to use cardboard drums lined with polyethylene film or sealed aluminum foil bags for packaging. This can not only prevent dust leakage caused by transportation vibration, but also isolate moisture and light, meeting the product storage requirements. The product name, CAS No., storage precautions and other information should be clearly marked on the outer packaging to facilitate identification and management in the logistics link.
3. Convenient Declaration: During customs declaration, only basic elements such as "product name, component content and purpose" need to be provided. No additional complex dangerous goods inspection reports are required, which complies with international trade and domestic customs supervision regulations, reduces the risk of declaration errors, and ensures efficient customs clearance of goods.
1. What is 2-chloromandelic acid?
2-Chloromandelic acid is an important organic compound that is primarily used as a pharmaceutical intermediate.
2. What are the main advantages of 2-chloromandelic acid?
These advantages include wide application, low production cost, and minimal impact on the environment.
3. Which industries use 2-chloromandelic acid?
It is widely used in the pharmaceutical, cosmetic, and food industries.
4. What is the use of 2-chloromandelic acid in medicine?
It is a key intermediate in the synthesis of drugs such as clopidogrel, which prevents blood clots.
5. What are the storage conditions for 2-chloromandelic acid?
Store 2-chloromandelic acid in a dark, dry place at room temperature to maintain its stability.
