Alverine Citrate (common name), with the chemical name N-Ethyl-3,3'-diphenyldipropylamine, is a research-grade compound with well-defined biological activity. Its CAS Number is 5560-59-8, molecular formula is C₂₆H₃₅NO₇, and molecular weight is 473.55900. The product appears as a solid and is primarily positioned as a 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist. It holds significant value in research on signal pathways related to metabolic diseases (especially those involving gastrointestinal function). This product is for scientific research use only and shall not be used as a drug, household medicine, or for other non-scientific research purposes.
Alverine Citrate exhibits stable physicochemical properties. Under standard atmospheric pressure (760 mmHg), its boiling point is 358.8ºC, flash point is 174.4ºC, LogP (octanol-water partition coefficient) is 3.32540, and Topological Polar Surface Area (TPSA) reaches 135.37000. Its molecular structure contains 4 Hydrogen Bond Donors, 8 Hydrogen Bond Acceptors, 14 Rotatable Bonds, and the number of covalent bond units is 2. The product must be stored hermetically in a dry environment at -20°C, which effectively ensures the stability of its physicochemical properties and biological activity, preventing functional failure caused by improper storage.
As a high-affinity 5-HT1A receptor antagonist, it has an IC₅₀ Value of 101 nM for the 5-HT1A receptor and only weak affinity for the 5-HT3 and 5-HT4 receptor subtypes, showing strong target specificity. In vitro and in vivo studies have confirmed that it can act directly on intestinal smooth muscle to relax it, inhibiting intestinal induced activity by reducing the sensitivity of contractile proteins to Ca²⁺. At the same time, it can reduce abdominal contractions caused by rectal distension by antagonizing the 5-HT1A receptor, exhibiting potential rectal analgesic-related effects. Additionally, it inhibits the inactivation of L-type calcium channels, which can regulate Ca²⁺ influx during action potentials. Its mechanism of action covers receptor regulation and ion channel effects, providing clear target references for relevant scientific research.
Alverine Citrate is a key tool compound for research on 5-HT receptor-related signal pathways, neural signal pathways, and the mechanism of intestinal smooth muscle function. It can be used for:
- Exploration of physiological and pathological processes mediated by the 5-HT1A receptor, such as verification of the molecular mechanisms of signal pathway activation and inhibition;
- Basic research on the pathogenesis of functional gastrointestinal disorders (e.g., irritable bowel syndrome), analyzing the association between intestinal smooth muscle regulation and 5-HT signaling;
- Activity screening and target validation in the early stage of drug development, providing a control standard for candidate drugs targeting the 5-HT1A receptor.
Based on its regulatory effect on intestinal smooth muscle and 5-HT1A receptor antagonistic activity, the research direction of this product focuses on its therapeutic potential for functional gastrointestinal disorders. However, it is currently only within the scope of research-grade applications and has not obtained clinical drug qualification. Further clinical research and compliance approval are required for the advancement of relevant medical applications.
This product is classified as a "non-hazardous substance or mixture" in accordance with the Globally Harmonized System of Classification and Labeling of Chemicals (GHS). Its Dangerous Goods Transport Code is NONH, which is applicable to all transportation methods (road, sea, and air) and does not require special control in accordance with dangerous goods transportation regulations.
- The package must remain hermetic during transportation to prevent dust leakage caused by package damage;
- It shall be kept away from high-temperature and humid environments, and the temperature inside the transport compartment or container shall be as close to room temperature as possible to avoid the impact of extreme temperatures on product stability;
- Transport documents shall clearly indicate the product name (Alverine Citrate), CAS Number (5560-59-8), and purpose (for scientific research) to meet the requirements of customs declaration and transportation supervision.
Alverine Citrate (common name), with the chemical name N-Ethyl-3,3'-diphenyldipropylamine, is a research-grade compound with well-defined biological activity. Its CAS Number is 5560-59-8, molecular formula is C₂₆H₃₅NO₇, and molecular weight is 473.55900. The product appears as a solid and is primarily positioned as a 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist. It holds significant value in research on signal pathways related to metabolic diseases (especially those involving gastrointestinal function). This product is for scientific research use only and shall not be used as a drug, household medicine, or for other non-scientific research purposes.
Alverine Citrate exhibits stable physicochemical properties. Under standard atmospheric pressure (760 mmHg), its boiling point is 358.8ºC, flash point is 174.4ºC, LogP (octanol-water partition coefficient) is 3.32540, and Topological Polar Surface Area (TPSA) reaches 135.37000. Its molecular structure contains 4 Hydrogen Bond Donors, 8 Hydrogen Bond Acceptors, 14 Rotatable Bonds, and the number of covalent bond units is 2. The product must be stored hermetically in a dry environment at -20°C, which effectively ensures the stability of its physicochemical properties and biological activity, preventing functional failure caused by improper storage.
As a high-affinity 5-HT1A receptor antagonist, it has an IC₅₀ Value of 101 nM for the 5-HT1A receptor and only weak affinity for the 5-HT3 and 5-HT4 receptor subtypes, showing strong target specificity. In vitro and in vivo studies have confirmed that it can act directly on intestinal smooth muscle to relax it, inhibiting intestinal induced activity by reducing the sensitivity of contractile proteins to Ca²⁺. At the same time, it can reduce abdominal contractions caused by rectal distension by antagonizing the 5-HT1A receptor, exhibiting potential rectal analgesic-related effects. Additionally, it inhibits the inactivation of L-type calcium channels, which can regulate Ca²⁺ influx during action potentials. Its mechanism of action covers receptor regulation and ion channel effects, providing clear target references for relevant scientific research.
Alverine Citrate is a key tool compound for research on 5-HT receptor-related signal pathways, neural signal pathways, and the mechanism of intestinal smooth muscle function. It can be used for:
- Exploration of physiological and pathological processes mediated by the 5-HT1A receptor, such as verification of the molecular mechanisms of signal pathway activation and inhibition;
- Basic research on the pathogenesis of functional gastrointestinal disorders (e.g., irritable bowel syndrome), analyzing the association between intestinal smooth muscle regulation and 5-HT signaling;
- Activity screening and target validation in the early stage of drug development, providing a control standard for candidate drugs targeting the 5-HT1A receptor.
Based on its regulatory effect on intestinal smooth muscle and 5-HT1A receptor antagonistic activity, the research direction of this product focuses on its therapeutic potential for functional gastrointestinal disorders. However, it is currently only within the scope of research-grade applications and has not obtained clinical drug qualification. Further clinical research and compliance approval are required for the advancement of relevant medical applications.
This product is classified as a "non-hazardous substance or mixture" in accordance with the Globally Harmonized System of Classification and Labeling of Chemicals (GHS). Its Dangerous Goods Transport Code is NONH, which is applicable to all transportation methods (road, sea, and air) and does not require special control in accordance with dangerous goods transportation regulations.
- The package must remain hermetic during transportation to prevent dust leakage caused by package damage;
- It shall be kept away from high-temperature and humid environments, and the temperature inside the transport compartment or container shall be as close to room temperature as possible to avoid the impact of extreme temperatures on product stability;
- Transport documents shall clearly indicate the product name (Alverine Citrate), CAS Number (5560-59-8), and purpose (for scientific research) to meet the requirements of customs declaration and transportation supervision.
