N,N'-Dicyclohexylcarbodiimide (DCC) is a widely used reagent in organic chemistry, known for its role as a dehydration and condensing agent. It is commonly used in biochemical and organic synthesis reactions, particularly for the formation of amide bonds. Its key applications include peptide and nucleic acid synthesis, making it an indispensable tool in pharmaceutical and biotechnology industries. DCC is also employed in the synthesis and dehydration of various compounds like amikacin, amino acids, acids, anhydrides, aldehydes, and ketones. The reagent plays a significant role in enhancing reaction efficiency by activating carboxyl groups, thus promoting bond formation in the reaction process.
DCC is a colorless or pale yellow liquid that remains stable under normal conditions. Its versatility extends across numerous fields, including the synthesis of antibiotics and other pharmaceuticals, due to its effective catalytic properties. It can also be utilized for the production of various other organic compounds, demonstrating its importance in both industrial and laboratory settings.
The product has stable and clear physicochemical parameters: the melting point is controlled at 34-35 °C (lit., indicating consistency with literature values); the boiling point is 122-124 °C under low-pressure conditions (6 torr) and 154-156 °C under normal pressure; the flash point is 87 °C, so fire protection should be noted. The density is 1.325 (in line with the conventional density unit g/cm³ or g/mL for organic compounds). It also has excellent solubility in organic solvents, being easily soluble in commonly used reaction solvents such as dichloromethane, tetrahydrofuran, acetonitrile, and N,N-dimethylformamide. However, it reacts with water, so it must be used in anhydrous systems. In addition, its Topological Polar Surface Area (PSA) is 24.72, and its Hydrophobic Parameter (LogP) reaches 5.54, which means its high hydrophobicity ensures better compatibility in non-polar reaction systems.
Under proper storage conditions (stored in a cool, dry, and well-ventilated warehouse, away from ignition sources, heat sources, and direct sunlight, with sealed packaging), the product is not prone to decomposition, and only needs to be kept away from oxides. Due to its strong hygroscopicity, it must be stored separately in a desiccator to prevent reduced reaction activity caused by moisture absorption. Meanwhile, it should be noted that this product is highly irritating to the skin. Therefore, rubber gloves must be worn during operation, and all operations should be conducted in a fume hood. This not only ensures the stability of the reagent but also reduces potential risks during use.
The product is labeled with clear GHS risk symbols (GHS05 for Corrosion, GHS07 for Harmful, GHS08 for Health Hazard) and the signal word "Danger". The core hazards include harmfulness if swallowed or in contact with the skin, causing skin/respiratory tract irritation, potential severe eye damage and allergic reactions, and possible organ damage upon long-term exposure. Strict compliance with protective requirements is necessary, such as wearing face shields, full-face respirators, goggles, and special filter cartridges. The risk points are clear and the protective measures are specific, facilitating standardized operations.
As a biochemical reagent, the core applications of N,N'-Dicyclohexylcarbodiimide focus on the fields of life science research and organic synthesis:
Relying on the activity of the carbodiimide functional group, this product is an efficient condensing agent. It can promote the reaction between carboxyl groups (-COOH) and amino groups (-NH₂), hydroxyl groups (-OH), etc., to form key chemical bonds such as amide bonds and ester bonds. It is widely used in peptide synthesis (e.g., preparation of peptide drug intermediates), synthesis of ester compounds (e.g., fine chemical raw materials), and synthesis of amide-based materials. Especially in anhydrous organic solvent systems, it shows significant advantages in reaction efficiency and selectivity.
As a biological material or organic compound, it can be used in scenarios such as cell signaling pathway research and biomolecule modification. For example, it assists in the coupling of small molecules with proteins in protein chemistry, or participates in probe labeling reactions in nucleic acid-related experiments. Currently, 186 literature reviews support its applications in specialized fields such as radiation damage protection, vertically aligned single-walled carbon nanotube (VASWCNT) electrode reactions, and drug carrier release, which confirms its research value and applicability in academic circles.
| Specification Item | Standard Requirements |
|--------------------------|---------------------------------------------------------------------------------------|
| Chemical Identification | CAS No. 538-75-0, molecular formula C₁₃H₂₂N₂, molecular weight 206.33, compliant with international naming standards for chemical reagents |
| Appearance and Character | White crystals or slightly yellow transparent liquid, no obvious impurities or peculiar smell |
| Core Physicochemical Parameters | Melting point 34-35 °C (lit.), boiling point 122-124 °C (6 torr) / 154-156 °C (normal pressure), flash point 87 °C |
| Purity and Impurity Control | Compliant with industrial-grade / laboratory-grade reagent standards (purity value not specified, but can be purified by vacuum distillation process) |
| Solubility | Easily soluble in organic solvents such as dichloromethane and tetrahydrofuran, reacts with water |
| Safety Compliance | Compliant with GHS safety standards, equipped with Chinese and English versions of Material Safety Data Sheet (MSDS) for risk management |
Since the product is a hazardous chemical, its transportation must strictly comply with international and domestic hazardous material transportation regulations:
Classified as Class 6.1 Toxic Substances, with a hazardous material transportation code of UN 2922 8/PG 2 (Class 8 Corrosive Substances, Packing Group II, medium risk). The compliance of the code and classification must be confirmed before transportation.
Adopt Packing Group II (suitable for medium-hazard substances). The packaging must be completely sealed to prevent leakage and moisture absorption. Meanwhile, clear safety labels (GHS symbols, signal words, hazard statements) should be marked.
During transportation, it must be kept away from ignition sources and heat sources, and protected from direct sunlight. Mixed loading and transportation with acids and food chemicals are strictly prohibited to prevent chemical reactions or contamination. The transport vehicle must be equipped with emergency containment materials for leakage, and the driver must be familiar with the product's safety characteristics and emergency handling measures.
For import and export, the Customs HS Code 2921300090 (classified as "other cyclic monoamines/polyamines, their derivatives and salts") must be used. During declaration, information such as product name, component content, and purpose must be provided. The tariff follows the standards of 6.5% for Most Favored Nation (MFN) and 30% for general trade. The VAT rate is 17%, and the tax rebate rate is 9%, with no special supervision conditions.
What is the primary use of N,N'-Dicyclohexylcarbodiimide (DCC)?
DCC is primarily used as a dehydration and condensing agent in organic synthesis, particularly for peptide and nucleic acid synthesis.
Can DCC be used in peptide synthesis?
Yes, DCC is widely used in peptide synthesis to activate carboxyl groups, facilitating the formation of amide bonds.
What is the solubility of DCC?
DCC is soluble in organic solvents like acetone, ethanol, and ether but is insoluble in water.
What are the safety precautions for handling DCC?
Protective gloves, goggles, and appropriate ventilation should be used when handling DCC to avoid irritation or exposure to its vapors.
What is the flash point of DCC?
The flash point of DCC is 190°F, indicating it is flammable and should be handled with caution.
How should DCC be stored?
DCC should be stored in a cool, dry place, away from heat, moisture, and direct sunlight to maintain stability and prevent decomposition.
For more information, visit our full range of chemicals here: Other Chemicals.
N,N'-Dicyclohexylcarbodiimide (DCC) is a widely used reagent in organic chemistry, known for its role as a dehydration and condensing agent. It is commonly used in biochemical and organic synthesis reactions, particularly for the formation of amide bonds. Its key applications include peptide and nucleic acid synthesis, making it an indispensable tool in pharmaceutical and biotechnology industries. DCC is also employed in the synthesis and dehydration of various compounds like amikacin, amino acids, acids, anhydrides, aldehydes, and ketones. The reagent plays a significant role in enhancing reaction efficiency by activating carboxyl groups, thus promoting bond formation in the reaction process.
DCC is a colorless or pale yellow liquid that remains stable under normal conditions. Its versatility extends across numerous fields, including the synthesis of antibiotics and other pharmaceuticals, due to its effective catalytic properties. It can also be utilized for the production of various other organic compounds, demonstrating its importance in both industrial and laboratory settings.
The product has stable and clear physicochemical parameters: the melting point is controlled at 34-35 °C (lit., indicating consistency with literature values); the boiling point is 122-124 °C under low-pressure conditions (6 torr) and 154-156 °C under normal pressure; the flash point is 87 °C, so fire protection should be noted. The density is 1.325 (in line with the conventional density unit g/cm³ or g/mL for organic compounds). It also has excellent solubility in organic solvents, being easily soluble in commonly used reaction solvents such as dichloromethane, tetrahydrofuran, acetonitrile, and N,N-dimethylformamide. However, it reacts with water, so it must be used in anhydrous systems. In addition, its Topological Polar Surface Area (PSA) is 24.72, and its Hydrophobic Parameter (LogP) reaches 5.54, which means its high hydrophobicity ensures better compatibility in non-polar reaction systems.
Under proper storage conditions (stored in a cool, dry, and well-ventilated warehouse, away from ignition sources, heat sources, and direct sunlight, with sealed packaging), the product is not prone to decomposition, and only needs to be kept away from oxides. Due to its strong hygroscopicity, it must be stored separately in a desiccator to prevent reduced reaction activity caused by moisture absorption. Meanwhile, it should be noted that this product is highly irritating to the skin. Therefore, rubber gloves must be worn during operation, and all operations should be conducted in a fume hood. This not only ensures the stability of the reagent but also reduces potential risks during use.
The product is labeled with clear GHS risk symbols (GHS05 for Corrosion, GHS07 for Harmful, GHS08 for Health Hazard) and the signal word "Danger". The core hazards include harmfulness if swallowed or in contact with the skin, causing skin/respiratory tract irritation, potential severe eye damage and allergic reactions, and possible organ damage upon long-term exposure. Strict compliance with protective requirements is necessary, such as wearing face shields, full-face respirators, goggles, and special filter cartridges. The risk points are clear and the protective measures are specific, facilitating standardized operations.
As a biochemical reagent, the core applications of N,N'-Dicyclohexylcarbodiimide focus on the fields of life science research and organic synthesis:
Relying on the activity of the carbodiimide functional group, this product is an efficient condensing agent. It can promote the reaction between carboxyl groups (-COOH) and amino groups (-NH₂), hydroxyl groups (-OH), etc., to form key chemical bonds such as amide bonds and ester bonds. It is widely used in peptide synthesis (e.g., preparation of peptide drug intermediates), synthesis of ester compounds (e.g., fine chemical raw materials), and synthesis of amide-based materials. Especially in anhydrous organic solvent systems, it shows significant advantages in reaction efficiency and selectivity.
As a biological material or organic compound, it can be used in scenarios such as cell signaling pathway research and biomolecule modification. For example, it assists in the coupling of small molecules with proteins in protein chemistry, or participates in probe labeling reactions in nucleic acid-related experiments. Currently, 186 literature reviews support its applications in specialized fields such as radiation damage protection, vertically aligned single-walled carbon nanotube (VASWCNT) electrode reactions, and drug carrier release, which confirms its research value and applicability in academic circles.
| Specification Item | Standard Requirements |
|--------------------------|---------------------------------------------------------------------------------------|
| Chemical Identification | CAS No. 538-75-0, molecular formula C₁₃H₂₂N₂, molecular weight 206.33, compliant with international naming standards for chemical reagents |
| Appearance and Character | White crystals or slightly yellow transparent liquid, no obvious impurities or peculiar smell |
| Core Physicochemical Parameters | Melting point 34-35 °C (lit.), boiling point 122-124 °C (6 torr) / 154-156 °C (normal pressure), flash point 87 °C |
| Purity and Impurity Control | Compliant with industrial-grade / laboratory-grade reagent standards (purity value not specified, but can be purified by vacuum distillation process) |
| Solubility | Easily soluble in organic solvents such as dichloromethane and tetrahydrofuran, reacts with water |
| Safety Compliance | Compliant with GHS safety standards, equipped with Chinese and English versions of Material Safety Data Sheet (MSDS) for risk management |
Since the product is a hazardous chemical, its transportation must strictly comply with international and domestic hazardous material transportation regulations:
Classified as Class 6.1 Toxic Substances, with a hazardous material transportation code of UN 2922 8/PG 2 (Class 8 Corrosive Substances, Packing Group II, medium risk). The compliance of the code and classification must be confirmed before transportation.
Adopt Packing Group II (suitable for medium-hazard substances). The packaging must be completely sealed to prevent leakage and moisture absorption. Meanwhile, clear safety labels (GHS symbols, signal words, hazard statements) should be marked.
During transportation, it must be kept away from ignition sources and heat sources, and protected from direct sunlight. Mixed loading and transportation with acids and food chemicals are strictly prohibited to prevent chemical reactions or contamination. The transport vehicle must be equipped with emergency containment materials for leakage, and the driver must be familiar with the product's safety characteristics and emergency handling measures.
For import and export, the Customs HS Code 2921300090 (classified as "other cyclic monoamines/polyamines, their derivatives and salts") must be used. During declaration, information such as product name, component content, and purpose must be provided. The tariff follows the standards of 6.5% for Most Favored Nation (MFN) and 30% for general trade. The VAT rate is 17%, and the tax rebate rate is 9%, with no special supervision conditions.
What is the primary use of N,N'-Dicyclohexylcarbodiimide (DCC)?
DCC is primarily used as a dehydration and condensing agent in organic synthesis, particularly for peptide and nucleic acid synthesis.
Can DCC be used in peptide synthesis?
Yes, DCC is widely used in peptide synthesis to activate carboxyl groups, facilitating the formation of amide bonds.
What is the solubility of DCC?
DCC is soluble in organic solvents like acetone, ethanol, and ether but is insoluble in water.
What are the safety precautions for handling DCC?
Protective gloves, goggles, and appropriate ventilation should be used when handling DCC to avoid irritation or exposure to its vapors.
What is the flash point of DCC?
The flash point of DCC is 190°F, indicating it is flammable and should be handled with caution.
How should DCC be stored?
DCC should be stored in a cool, dry place, away from heat, moisture, and direct sunlight to maintain stability and prevent decomposition.
For more information, visit our full range of chemicals here: Other Chemicals.
