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Alpha-Ketoglutaric Acid CAS 328-50-7

α-ketoglutaric acid is an important biomolecule, one of the important intermediate products in the tricarboxylic acid cycle, and a symbiotic substance in nitrogen transporter and molecular oxidation. It plays an important role in the metabolism of microbial cells and is also an important precursor for the synthesis of various amino acids and proteins.
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Product Name

Alpha-Ketoglutaric acid

Synonyms 2-Oxoglutaric acid; 2-Oxopentanedioic acid; 2-Ketoglutaric acid; alpha-Ketoglutaric Acid; A-KETOGLUTARIC ACID; GAMMA-KETOGLUTARIC ACID; FEMA 3891; KETO-GLU; PENTANEDIOIC ACID, 2-OXO-; 2-Oxo-1,5-dipentanedioic acid; 2-Oxo-1,5-pentanedioic acid; 2-oxo-pentanedioicaci; 2-Oxpentanedioicacid; Glutaric acid, 2-oxo-; Glutaric acid, alpha keto; -Ketoglutaricacid; α-Ketoglutaricacid; A-KETOGLUTARIC ACID FREE ACID CELL*CULTU RE TESTED; A-KETOGLUTARIC ACID FREE ACID; 2-KETOGLUTARIC ACID BIOSYNTH
Molecular Formula C5H6O5
Molecular Weight 146.1
CAS Registry Number

328-50-7

Molecular Structure Alpha-Ketoglutaric acid
Product Application Mainly as a component of sports nutrition drinks


Names and Identifiers


Alpha-Ketoglutaric acid, also known as 2-Oxoglutaric acid, Alpha-Ketoglutarate, or AKG, has the CAS number 328-50-7.

The molecular formula is C5H6O5, and its molecular weight is 146.1 g/mol.

It is commonly referred to as a metabolic intermediate and is important in amino acid metabolism.


Chemical Properties


Alpha-Ketoglutaric Acid is slightly soluble in water. 

It is stable under standard storage conditions but may change color over time. 

It has a melting point of 113–115°C, a boiling point of 320.7°C, and a flash point of 147.7°C. 

It appears as a white crystalline powder and has a density of 1.54 g/cm³.


Product Advantages


  • Supports Metabolism: Plays a key role in the Krebs cycle, enhancing cellular energy production.

  • Athletic Performance: Commonly used in sports nutrition drinks to support physical endurance and muscle recovery.

  • Versatile Applications: Used in organic synthesis, as a reagent in enzyme determination, and in liver function tests.

  • Health Supplement: Serves as a raw material for developing medicines and health products, supporting overall well-being.


Production Usage


It is used in enzyme activity determination as a substrate for amino-converting enzymes and dehydrogenase. 

It is also a supporting reagent in liver function tests. 

In sports nutrition, it aids in energy production and muscle recovery. 

As a raw material and food additive, it supports health products and medicines. 

It serves as an analytical reagent for tryptophan and is valuable in enzyme activity studies. 

In organic synthesis, it acts as an intermediate in the Krebs cycle, essential for producing various organic compounds.


Safety and Storage


It should be handled with care to avoid contact with water, as it may be harmful to the environment. 

It should be stored between 2–8°C to maintain its quality and stability. 

Follow standard laboratory and manufacturing safety guidelines when handling it.


FAQs


Q1: What is Alpha-Ketoglutaric acid used for?

A1: Alpha-Ketoglutaric acid is primarily used in sports nutrition, organic synthesis, and as a reagent in enzyme activity studies.


Q2: Is Alpha-Ketoglutaric acid soluble in water?

A2: It is slightly soluble in water, allowing it to participate effectively in biological and metabolic processes.


Q3: How should Alpha-Ketoglutaric acid be stored?

A3: It should be stored at temperatures between 2–8°C to ensure optimal quality.


Q4: What are the benefits of using Alpha-Ketoglutaric acid in sports nutrition?

A4: It helps in enhancing energy production, supporting muscle recovery, and improving athletic performance.


Q5: Is Alpha-Ketoglutaric acid safe to use in food and health products?

A5: Yes, when used within regulated guidelines, it is safe for inclusion in nutritional supplements and health products.

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