α-Ketoglutaric Acid (chemical name: 2-Oxoglutaric Acid; English name: 2-Ketoglutaric Acid) is an organic carboxylic acid with crucial physiological activity, with a CAS number of 328-50-7, a molecular formula of C₅H₆O₅, and a molecular weight of 146.098. It appears as a white fine crystalline powder with a delicate texture; upon long-term storage, it may gradually turn pale yellow-gray due to environmental factors and is prone to deliquescence, requiring sealed storage under specific conditions.
As an endogenous metabolite in the human body, this substance is not an "exogenous chemical" synthesized artificially, but a core intermediate molecule naturally present in tobacco leaves, tobacco smoke, and human metabolic pathways. It not only participates deeply in the "Tricarboxylic Acid Cycle (TCA Cycle)" of cellular energy metabolism but also connects the metabolic networks of glutamic acid and glutamine through transamination. It serves as an important "bridge" substance for maintaining the body's energy supply and nitrogen metabolism balance, holding an irreplaceable fundamental position in the field of biochemical research.
The product has clear thermodynamic parameters: melting point of 113-115°C (with an accurate value of 113.5°C), boiling point of 345.6±25.0°C (under 760 mmHg atmospheric pressure), flash point of 177.0±19.7°C, density of 1.5±0.1 g/cm³, and refractive index of 1.494. Its physicochemical properties are stable in conventional laboratory environments. In terms of solubility, it is "completely soluble in water, easily soluble in alcohols, and extremely slightly soluble in ether," facilitating the selection of solvent systems based on experimental needs. Additionally, its vapor pressure is extremely low (only 0.0±1.6 mmHg at 25°C), reducing volatile losses during storage and operation.
Its core biological target is "Human Endogenous Metabolite" rather than an exogenous functional molecule. Therefore, in research fields such as metabolomics and cell biology, it can more truly simulate the physiological state of the human body and avoid interference from exogenous substances on the experimental system. Currently, there are 74 relevant literature reviews supporting its application in metabolic research, covering research directions such as mouse models of metabolic disorders, pathological analysis of organic acids in cerebrospinal fluid, and the establishment of reference values for organic acids in children's urine, enjoying high academic recognition.
The product is labeled with the GHS05 corrosive substance symbol and the "Danger" signal word, clearly stating the hazard statement "H318 (Causes serious eye damage)." It also provides a complete protection plan (N95 dust mask, eye shields, protective gloves) and emergency treatment measures (e.g., immediate rinsing with water and medical attention if it enters the eyes), featuring strong risk controllability and compliance with safety management standards for scientific research reagents.
As a basic scientific research reagent, α-Ketoglutaric Acid is mainly applied in the fields of biochemistry and medical research, including:
It is used to construct in vitro simulation systems of the TCA cycle to explore the regulatory mechanisms of key steps in cellular energy metabolism. Meanwhile, it can serve as a substrate in transamination experiments to analyze the associated effects of glutamic acid and glutamine metabolic networks, providing material support for mechanism research in fields such as diabetes and liver metabolic diseases.
Based on the "capillary gas chromatography-mass spectrometry (GC-MS)" method reported in literature, it can be used as a reference standard for detecting the content of α-Ketoglutaric Acid in plasma and cerebrospinal fluid, supporting the diagnosis of metabolic disorders (e.g., organic acidemia) in clinical fields such as pediatrics and neurology.
In metabolomics research on animal models such as mice and rats, exogenous supplementation of this substance can be used to observe changes in metabolic fingerprints in urine and tissue samples, analyze the effects of factors such as diet induction and drug intervention on body metabolism, and provide data support for precision medicine research.
| Specification Category | Specific Parameters | Description |
|------------------------------|-----------------------------------------------|------------------------------------------|
| Basic Identification | CAS No.: 328-50-7 | Globally unique chemical identification code |
| Molecular Information | Molecular Formula: C₅H₆O₅; Molecular Weight: 146.098 | Conforms to the structural characteristics of organic carboxylic acids |
| Physicochemical Parameters | Melting Point: 113-115°C; Boiling Point: 345.6±25.0°C | Determined under 760 mmHg atmospheric pressure |
| Solubility | Water Solubility: Fully soluble; Alcohol Solubility: Easily soluble | Extremely slightly soluble in ether, applicable for solvent separation and purification |
| Storage Conditions | Sealed storage at 2-8°C | Moisture-proof and light-proof, avoiding discoloration due to long-term storage |
| Customs Code | 2918300090 | Applicable for international trade declaration, no special supervision requirements |
The product has a hazardous material transportation code of "NONH" and is suitable for all conventional transportation methods such as road, railway, and air transportation. No special transportation qualifications are required, but it must be packaged separately to avoid mixing with daily necessities such as food and pharmaceuticals.
Temperature-controlled shipping containers (maintaining 2-8°C) with built-in moisture absorbents (e.g., silica gel desiccants) must be used to prevent deliquescence or changes in crystal form caused by temperature fluctuations during transportation. Warning labels such as "Corrosive Substance" and "Moisture-Proof" should be affixed to the outer layer of the packaging to remind transport personnel to take protective measures.
Upon receipt of the goods, the integrity of the packaging (no damage or leakage) should be checked immediately, and the product should be quickly transferred to a refrigerator at 2-8°C for storage. At the same time, observe whether the appearance is white fine crystals (if obvious yellow-gray discoloration or caking occurs, it is necessary to check whether deterioration is caused by improper transportation conditions).
Q1: What is Alpha-Ketoglutaric acid used for?
A1: Alpha-Ketoglutaric acid is primarily used in sports nutrition, organic synthesis, and as a reagent in enzyme activity studies.
Q2: Is Alpha-Ketoglutaric acid soluble in water?
A2: It is slightly soluble in water, allowing it to participate effectively in biological and metabolic processes.
Q3: How should Alpha-Ketoglutaric acid be stored?
A3: It should be stored at temperatures between 2–8°C to ensure optimal quality.
Q4: What are the benefits of using Alpha-Ketoglutaric acid in sports nutrition?
A4: It helps in enhancing energy production, supporting muscle recovery, and improving athletic performance.
Q5: Is Alpha-Ketoglutaric acid safe to use in food and health products?
A5: Yes, when used within regulated guidelines, it is safe for inclusion in nutritional supplements and health products.
α-Ketoglutaric Acid (chemical name: 2-Oxoglutaric Acid; English name: 2-Ketoglutaric Acid) is an organic carboxylic acid with crucial physiological activity, with a CAS number of 328-50-7, a molecular formula of C₅H₆O₅, and a molecular weight of 146.098. It appears as a white fine crystalline powder with a delicate texture; upon long-term storage, it may gradually turn pale yellow-gray due to environmental factors and is prone to deliquescence, requiring sealed storage under specific conditions.
As an endogenous metabolite in the human body, this substance is not an "exogenous chemical" synthesized artificially, but a core intermediate molecule naturally present in tobacco leaves, tobacco smoke, and human metabolic pathways. It not only participates deeply in the "Tricarboxylic Acid Cycle (TCA Cycle)" of cellular energy metabolism but also connects the metabolic networks of glutamic acid and glutamine through transamination. It serves as an important "bridge" substance for maintaining the body's energy supply and nitrogen metabolism balance, holding an irreplaceable fundamental position in the field of biochemical research.
The product has clear thermodynamic parameters: melting point of 113-115°C (with an accurate value of 113.5°C), boiling point of 345.6±25.0°C (under 760 mmHg atmospheric pressure), flash point of 177.0±19.7°C, density of 1.5±0.1 g/cm³, and refractive index of 1.494. Its physicochemical properties are stable in conventional laboratory environments. In terms of solubility, it is "completely soluble in water, easily soluble in alcohols, and extremely slightly soluble in ether," facilitating the selection of solvent systems based on experimental needs. Additionally, its vapor pressure is extremely low (only 0.0±1.6 mmHg at 25°C), reducing volatile losses during storage and operation.
Its core biological target is "Human Endogenous Metabolite" rather than an exogenous functional molecule. Therefore, in research fields such as metabolomics and cell biology, it can more truly simulate the physiological state of the human body and avoid interference from exogenous substances on the experimental system. Currently, there are 74 relevant literature reviews supporting its application in metabolic research, covering research directions such as mouse models of metabolic disorders, pathological analysis of organic acids in cerebrospinal fluid, and the establishment of reference values for organic acids in children's urine, enjoying high academic recognition.
The product is labeled with the GHS05 corrosive substance symbol and the "Danger" signal word, clearly stating the hazard statement "H318 (Causes serious eye damage)." It also provides a complete protection plan (N95 dust mask, eye shields, protective gloves) and emergency treatment measures (e.g., immediate rinsing with water and medical attention if it enters the eyes), featuring strong risk controllability and compliance with safety management standards for scientific research reagents.
As a basic scientific research reagent, α-Ketoglutaric Acid is mainly applied in the fields of biochemistry and medical research, including:
It is used to construct in vitro simulation systems of the TCA cycle to explore the regulatory mechanisms of key steps in cellular energy metabolism. Meanwhile, it can serve as a substrate in transamination experiments to analyze the associated effects of glutamic acid and glutamine metabolic networks, providing material support for mechanism research in fields such as diabetes and liver metabolic diseases.
Based on the "capillary gas chromatography-mass spectrometry (GC-MS)" method reported in literature, it can be used as a reference standard for detecting the content of α-Ketoglutaric Acid in plasma and cerebrospinal fluid, supporting the diagnosis of metabolic disorders (e.g., organic acidemia) in clinical fields such as pediatrics and neurology.
In metabolomics research on animal models such as mice and rats, exogenous supplementation of this substance can be used to observe changes in metabolic fingerprints in urine and tissue samples, analyze the effects of factors such as diet induction and drug intervention on body metabolism, and provide data support for precision medicine research.
| Specification Category | Specific Parameters | Description |
|------------------------------|-----------------------------------------------|------------------------------------------|
| Basic Identification | CAS No.: 328-50-7 | Globally unique chemical identification code |
| Molecular Information | Molecular Formula: C₅H₆O₅; Molecular Weight: 146.098 | Conforms to the structural characteristics of organic carboxylic acids |
| Physicochemical Parameters | Melting Point: 113-115°C; Boiling Point: 345.6±25.0°C | Determined under 760 mmHg atmospheric pressure |
| Solubility | Water Solubility: Fully soluble; Alcohol Solubility: Easily soluble | Extremely slightly soluble in ether, applicable for solvent separation and purification |
| Storage Conditions | Sealed storage at 2-8°C | Moisture-proof and light-proof, avoiding discoloration due to long-term storage |
| Customs Code | 2918300090 | Applicable for international trade declaration, no special supervision requirements |
The product has a hazardous material transportation code of "NONH" and is suitable for all conventional transportation methods such as road, railway, and air transportation. No special transportation qualifications are required, but it must be packaged separately to avoid mixing with daily necessities such as food and pharmaceuticals.
Temperature-controlled shipping containers (maintaining 2-8°C) with built-in moisture absorbents (e.g., silica gel desiccants) must be used to prevent deliquescence or changes in crystal form caused by temperature fluctuations during transportation. Warning labels such as "Corrosive Substance" and "Moisture-Proof" should be affixed to the outer layer of the packaging to remind transport personnel to take protective measures.
Upon receipt of the goods, the integrity of the packaging (no damage or leakage) should be checked immediately, and the product should be quickly transferred to a refrigerator at 2-8°C for storage. At the same time, observe whether the appearance is white fine crystals (if obvious yellow-gray discoloration or caking occurs, it is necessary to check whether deterioration is caused by improper transportation conditions).
Q1: What is Alpha-Ketoglutaric acid used for?
A1: Alpha-Ketoglutaric acid is primarily used in sports nutrition, organic synthesis, and as a reagent in enzyme activity studies.
Q2: Is Alpha-Ketoglutaric acid soluble in water?
A2: It is slightly soluble in water, allowing it to participate effectively in biological and metabolic processes.
Q3: How should Alpha-Ketoglutaric acid be stored?
A3: It should be stored at temperatures between 2–8°C to ensure optimal quality.
Q4: What are the benefits of using Alpha-Ketoglutaric acid in sports nutrition?
A4: It helps in enhancing energy production, supporting muscle recovery, and improving athletic performance.
Q5: Is Alpha-Ketoglutaric acid safe to use in food and health products?
A5: Yes, when used within regulated guidelines, it is safe for inclusion in nutritional supplements and health products.
