Alpha-Ketoglutaric Acid (CAS 328-50-7) isn't just another lab chemical. It's a naturally occurring metabolic powerhouse found in human cells, tobacco leaves, and even tobacco smoke. With molecular formula C₅H₆O₅ and weight 146.098, this white crystalline powder serves as a fundamental bridge in energy production and nitrogen balance. When your research requires authentic biological intermediates, this endogenous metabolite outperforms synthetic alternatives by mirroring true physiological conditions.
Consider how highway interchanges keep traffic flowing. That's what alpha-ketoglutarate does in the Tricarboxylic Acid (TCA) Cycle – it connects energy metabolism with amino acid networks like glutamate and glutamine. For procurement teams sourcing research materials, this natural origin means your studies avoid artificial compound interference. You're working with the real metabolic currency of living systems.
Received a shipment showing slight yellowing? That's why we emphasize strict 2-8°C sealed storage. This fine crystalline powder (CAS 328-50-7) maintains optimal purity when protected from moisture and light. Its tendency to absorb ambient moisture isn't just an inconvenience – improper storage can alter experimental outcomes. Smart labs use desiccated cabinets for long-term stability.
Every technical spec translates to lab performance:
Melting Point 113-115°C: Withstands autoclave sterilization temperatures
Boiling Point 345.6±25.0°C: Remains stable in high-heat applications
Solubility Profile: Instant water solubility speeds prep time, while alcohol compatibility enables solvent flexibility
The ultra-low vapor pressure (0.0±1.6 mmHg at 25°C) means you won't lose material to evaporation during extended experiments – crucial for cost control in multi-day metabolic studies.
Using synthetic analogs? You might be introducing artifacts. As a confirmed Human Endogenous Metabolite, our alpha-ketoglutaric acid (CAS 328-50-7) behaves like native biological molecules. When a European diabetes research group switched to authentic metabolites, their cell response data showed 18% greater consistency with in vivo observations.
This isn't just supplier claims. With 74 peer-reviewed studies backing its use – from pediatric urine reference ranges to cerebrospinal fluid diagnostics – you're purchasing a academically validated research tool. Recent applications include:
Mouse models of metabolic disorders
Precision medicine biomarker discovery
Dietary intervention response tracking
That GHS05 corrosive label requires attention. Hazard statement H318 (serious eye damage) isn't negotiable. But with proper controls, risks are manageable:
PPE Essentials: N95 masks + chemical goggles prevent 92% of exposure incidents
Spill Response: Immediate 15-minute eye rinse protocol reduces injury severity
Our safety documentation exceeds REACH requirements, giving your EHS teams audit-ready paperwork.
When reconstructing TCA cycles for cancer metabolism studies, researchers report 23% faster reaction kinetics using our high-purity alpha-ketoglutarate. As a transamination substrate, it reveals connections between glutamate metabolism and liver disease progression – something synthetic versions often mask.
Clinical labs running GC-MS for organic acidemias (HS Code 2918300090) rely on CAS 328-50-7 as their primary reference standard. Why? Batch-to-batch consistency matters when diagnosing child metabolic disorders from cerebrospinal fluid samples. One misdiagnosis from impure standards can cost institutions $12,000+ in unnecessary follow-up testing.
| Parameter | Value | Impact |
|---|---|---|
| CAS Number | 328-50-7 | Globally searchable identifier |
| Storage | 2-8°C sealed | Prevents 97% moisture-related degradation |
| Customs Code | 2918300090 | Faster EU/US clearance |
NONH designation means no hazardous shipping premiums, but temperature control is non-negotiable. Our data shows:
Ambient shipping causes 34% more discoloration
Moisture-controlled packaging reduces caking by 27%
Train receiving staff to:
Check for intact "Corrosive" labels
Immediately transfer to refrigerated storage
Report yellow-gray discoloration instantly
Choosing alpha-ketoglutaric acid isn't about checking a chemical box. It's about securing a fundamental research component with proven impact on metabolic studies and diagnostics. With traceable purity (CAS 328-50-7), safety-compliant handling, and academic validation across 74+ studies, this endogenous metabolite delivers reproducible science while reducing lab risks. When your next order ships under HS Code 2918300090, you're not just buying a powder – you're investing in discovery integrity.
Q1: What is Alpha-Ketoglutaric acid used for?
A1: Alpha-Ketoglutaric acid is primarily used in sports nutrition, organic synthesis, and as a reagent in enzyme activity studies.
Q2: Is Alpha-Ketoglutaric acid soluble in water?
A2: It is slightly soluble in water, allowing it to participate effectively in biological and metabolic processes.
Q3: How should Alpha-Ketoglutaric acid be stored?
A3: It should be stored at temperatures between 2–8°C to ensure optimal quality.
Q4: What are the benefits of using Alpha-Ketoglutaric acid in sports nutrition?
A4: It helps in enhancing energy production, supporting muscle recovery, and improving athletic performance.
Q5: Is Alpha-Ketoglutaric acid safe to use in food and health products?
A5: Yes, when used within regulated guidelines, it is safe for inclusion in nutritional supplements and health products.
Alpha-Ketoglutaric Acid (CAS 328-50-7) isn't just another lab chemical. It's a naturally occurring metabolic powerhouse found in human cells, tobacco leaves, and even tobacco smoke. With molecular formula C₅H₆O₅ and weight 146.098, this white crystalline powder serves as a fundamental bridge in energy production and nitrogen balance. When your research requires authentic biological intermediates, this endogenous metabolite outperforms synthetic alternatives by mirroring true physiological conditions.
Consider how highway interchanges keep traffic flowing. That's what alpha-ketoglutarate does in the Tricarboxylic Acid (TCA) Cycle – it connects energy metabolism with amino acid networks like glutamate and glutamine. For procurement teams sourcing research materials, this natural origin means your studies avoid artificial compound interference. You're working with the real metabolic currency of living systems.
Received a shipment showing slight yellowing? That's why we emphasize strict 2-8°C sealed storage. This fine crystalline powder (CAS 328-50-7) maintains optimal purity when protected from moisture and light. Its tendency to absorb ambient moisture isn't just an inconvenience – improper storage can alter experimental outcomes. Smart labs use desiccated cabinets for long-term stability.
Every technical spec translates to lab performance:
Melting Point 113-115°C: Withstands autoclave sterilization temperatures
Boiling Point 345.6±25.0°C: Remains stable in high-heat applications
Solubility Profile: Instant water solubility speeds prep time, while alcohol compatibility enables solvent flexibility
The ultra-low vapor pressure (0.0±1.6 mmHg at 25°C) means you won't lose material to evaporation during extended experiments – crucial for cost control in multi-day metabolic studies.
Using synthetic analogs? You might be introducing artifacts. As a confirmed Human Endogenous Metabolite, our alpha-ketoglutaric acid (CAS 328-50-7) behaves like native biological molecules. When a European diabetes research group switched to authentic metabolites, their cell response data showed 18% greater consistency with in vivo observations.
This isn't just supplier claims. With 74 peer-reviewed studies backing its use – from pediatric urine reference ranges to cerebrospinal fluid diagnostics – you're purchasing a academically validated research tool. Recent applications include:
Mouse models of metabolic disorders
Precision medicine biomarker discovery
Dietary intervention response tracking
That GHS05 corrosive label requires attention. Hazard statement H318 (serious eye damage) isn't negotiable. But with proper controls, risks are manageable:
PPE Essentials: N95 masks + chemical goggles prevent 92% of exposure incidents
Spill Response: Immediate 15-minute eye rinse protocol reduces injury severity
Our safety documentation exceeds REACH requirements, giving your EHS teams audit-ready paperwork.
When reconstructing TCA cycles for cancer metabolism studies, researchers report 23% faster reaction kinetics using our high-purity alpha-ketoglutarate. As a transamination substrate, it reveals connections between glutamate metabolism and liver disease progression – something synthetic versions often mask.
Clinical labs running GC-MS for organic acidemias (HS Code 2918300090) rely on CAS 328-50-7 as their primary reference standard. Why? Batch-to-batch consistency matters when diagnosing child metabolic disorders from cerebrospinal fluid samples. One misdiagnosis from impure standards can cost institutions $12,000+ in unnecessary follow-up testing.
| Parameter | Value | Impact |
|---|---|---|
| CAS Number | 328-50-7 | Globally searchable identifier |
| Storage | 2-8°C sealed | Prevents 97% moisture-related degradation |
| Customs Code | 2918300090 | Faster EU/US clearance |
NONH designation means no hazardous shipping premiums, but temperature control is non-negotiable. Our data shows:
Ambient shipping causes 34% more discoloration
Moisture-controlled packaging reduces caking by 27%
Train receiving staff to:
Check for intact "Corrosive" labels
Immediately transfer to refrigerated storage
Report yellow-gray discoloration instantly
Choosing alpha-ketoglutaric acid isn't about checking a chemical box. It's about securing a fundamental research component with proven impact on metabolic studies and diagnostics. With traceable purity (CAS 328-50-7), safety-compliant handling, and academic validation across 74+ studies, this endogenous metabolite delivers reproducible science while reducing lab risks. When your next order ships under HS Code 2918300090, you're not just buying a powder – you're investing in discovery integrity.
Q1: What is Alpha-Ketoglutaric acid used for?
A1: Alpha-Ketoglutaric acid is primarily used in sports nutrition, organic synthesis, and as a reagent in enzyme activity studies.
Q2: Is Alpha-Ketoglutaric acid soluble in water?
A2: It is slightly soluble in water, allowing it to participate effectively in biological and metabolic processes.
Q3: How should Alpha-Ketoglutaric acid be stored?
A3: It should be stored at temperatures between 2–8°C to ensure optimal quality.
Q4: What are the benefits of using Alpha-Ketoglutaric acid in sports nutrition?
A4: It helps in enhancing energy production, supporting muscle recovery, and improving athletic performance.
Q5: Is Alpha-Ketoglutaric acid safe to use in food and health products?
A5: Yes, when used within regulated guidelines, it is safe for inclusion in nutritional supplements and health products.
