Choline Chloride, CAS 67-48-1, is a vital quaternary ammonium salt that plays a critical role in lipid metabolism and acetylcholine synthesis. Presented as adhering white crystals, it is highly soluble in water and alcohol, with a salty-bitter taste and fish-like odor. Known for its deliquescence, Choline Chloride is widely recognized for its medical, agricultural, and industrial applications. It is extensively used to treat fatty liver and cirrhosis in medicine and as a feed additive to improve the growth, health, and productivity of livestock and aquatic animals. Moreover, it serves as an effective growth promoter in agriculture, enhancing crop yield and resistance.
Choline Chloride is a white crystalline powder with a distinctive fish-like odor and bitter-salty taste, molecular formula C₅H₁₄ClNO. As a naturally occurring quaternary ammonium salt in living organisms, it serves as both a core component of Vitamin B₄ and a critical carrier for biomembrane synthesis and lipid metabolism. Manufactured via the ethylene oxide process with ≥98% purity, it complies with FDA, FEMA, and feed-grade safety standards. Global annual production exceeds 400,000 MT, with China dominating the supply chain.
Pharmaceutical Grade: Activates hepatic lipid-metabolizing enzymes, reducing cirrhosis treatment costs by 30%.
Feed Grade: Replaces 50% of methionine demand, significantly lowering feed formulation expenses.
Heat-resistant (decomposes at 302°C), zero activity loss during feed pelleting.
Aqueous solution pH 5.0-7.5, compatible with diverse compound additives.
Rat oral LD₅₀ = 6640 mg/kg (practically non-toxic).
Biodegradation rate >99%, no environmental residue risk.
| Parameter | Specification |
|---|---|
| Molecular Weight | 139.62 g/mol |
| Density | 1.0238 g/cm³ (crystal) |
| Solubility | >650 g/L in water (20°C) |
| Hygroscopicity | ≤0.5% moisture gain (RH65%, 24h) |
| Critical Restriction | Incompatible with Vitamins A/D₃ |
Animal Nutrition Innovation
Poultry Farming: 1-2 g/kg feed increases egg production by 15% and reduces yolk cholesterol by 20%.
Aquafeed: Enhances stress resistance in fish/shrimp, decreasing intramuscular fat deposition by 35%.
Agricultural Yield Booster
Root Crops: 20 ml/mu of 60% aqueous solution at bulking stage boosts sweet potato yield by 30%.
Cereal Resilience: Foliar spray during jointing stage reduces wheat lodging rate by 40%.
Pharmaceutical & Health
Liver Therapy Injectables: Increases ALT normalization rate by 56% in fatty liver patients.
Infant Formula: ≤50 mg/100g (per GB 14880).
Packaging:
Pharma Grade: 25 kg/drum (nitrogen-flushed with aluminum foil liner).
Feed Grade: 1 MT/IBC tote (moisture-proof film + woven sack).
Shipping Requirements:
Ocean Transport: UN3077 CLASS 9 (Environmentally Hazardous Substance).
Land Transport: Rainproof and dry; avoid oxidizer co-shipment.
Storage Conditions:
Cool, dry warehouse (humidity ≤65%).
Shelf life: 36 months in original packaging.
| Test Item | Standard | Method |
|---|---|---|
| Assay | ≥98.0% | HPLC |
| Heavy Metals (Pb) | ≤5 ppm | AAS |
| Trimethylamine Residue | ≤50 ppm | GC-MS |
| Residue on Ignition | ≤0.1% | Muffle Furnace |
De Heus Group (Netherlands):
"Adding 0.1% choline chloride to broiler feed reduced FCR from 1.75 to 1.62, saving €12.8/MT feed cost."Shouguang Vegetable Base (China):
"0.3% foliar spray during tomato ripening decreased fruit cracking by 28% and increased single-fruit weight by 22%."Sun Pharma (India):
"Adjuvant therapy for fatty liver showed 41% higher efficacy vs. monotherapy (P<0.01)."
As a methyl donor and phospholipid synthesis catalyst, choline chloride delivers:
Livestock: ¥35 extra profit per market hog
Agriculture: ¥500+/mu added value for cash crops
Pharma: 40% lower treatment cost for liver diseases
With China supplying 56% of global capacity, supply chain stability reaches 99.7%.
Q1: Is Choline Chloride safe for animal feed use?
A1: Yes, Choline Chloride is safe and widely used in animal feed formulations to promote growth, health, and productivity.
Q2: Can Choline Chloride be used in human medicine?
A2: Yes, it is used in treating fatty liver and cirrhosis by supporting lipid metabolism and aiding acetylcholine synthesis.
Q3: How is Choline Chloride applied in agriculture?
A3: It is sprayed during crop growth stages to enhance photosynthesis and yield.
Q4: What storage precautions are necessary?
A4: Store in a dry, sealed environment at room temperature to prevent deliquescence. Dehumidifiers are recommended for long-term storage.
Q5: Where can I find more details about related chemicals?
A5: Visit JIANGYIN TRUST INTERNATIONAL's product page for additional information.
For comprehensive solutions, JIANGYIN TRUST INTERNATIONAL ensures quality and consistency in every product we deliver.
Choline Chloride, CAS 67-48-1, is a vital quaternary ammonium salt that plays a critical role in lipid metabolism and acetylcholine synthesis. Presented as adhering white crystals, it is highly soluble in water and alcohol, with a salty-bitter taste and fish-like odor. Known for its deliquescence, Choline Chloride is widely recognized for its medical, agricultural, and industrial applications. It is extensively used to treat fatty liver and cirrhosis in medicine and as a feed additive to improve the growth, health, and productivity of livestock and aquatic animals. Moreover, it serves as an effective growth promoter in agriculture, enhancing crop yield and resistance.
Choline Chloride is a white crystalline powder with a distinctive fish-like odor and bitter-salty taste, molecular formula C₅H₁₄ClNO. As a naturally occurring quaternary ammonium salt in living organisms, it serves as both a core component of Vitamin B₄ and a critical carrier for biomembrane synthesis and lipid metabolism. Manufactured via the ethylene oxide process with ≥98% purity, it complies with FDA, FEMA, and feed-grade safety standards. Global annual production exceeds 400,000 MT, with China dominating the supply chain.
Pharmaceutical Grade: Activates hepatic lipid-metabolizing enzymes, reducing cirrhosis treatment costs by 30%.
Feed Grade: Replaces 50% of methionine demand, significantly lowering feed formulation expenses.
Heat-resistant (decomposes at 302°C), zero activity loss during feed pelleting.
Aqueous solution pH 5.0-7.5, compatible with diverse compound additives.
Rat oral LD₅₀ = 6640 mg/kg (practically non-toxic).
Biodegradation rate >99%, no environmental residue risk.
| Parameter | Specification |
|---|---|
| Molecular Weight | 139.62 g/mol |
| Density | 1.0238 g/cm³ (crystal) |
| Solubility | >650 g/L in water (20°C) |
| Hygroscopicity | ≤0.5% moisture gain (RH65%, 24h) |
| Critical Restriction | Incompatible with Vitamins A/D₃ |
Animal Nutrition Innovation
Poultry Farming: 1-2 g/kg feed increases egg production by 15% and reduces yolk cholesterol by 20%.
Aquafeed: Enhances stress resistance in fish/shrimp, decreasing intramuscular fat deposition by 35%.
Agricultural Yield Booster
Root Crops: 20 ml/mu of 60% aqueous solution at bulking stage boosts sweet potato yield by 30%.
Cereal Resilience: Foliar spray during jointing stage reduces wheat lodging rate by 40%.
Pharmaceutical & Health
Liver Therapy Injectables: Increases ALT normalization rate by 56% in fatty liver patients.
Infant Formula: ≤50 mg/100g (per GB 14880).
Packaging:
Pharma Grade: 25 kg/drum (nitrogen-flushed with aluminum foil liner).
Feed Grade: 1 MT/IBC tote (moisture-proof film + woven sack).
Shipping Requirements:
Ocean Transport: UN3077 CLASS 9 (Environmentally Hazardous Substance).
Land Transport: Rainproof and dry; avoid oxidizer co-shipment.
Storage Conditions:
Cool, dry warehouse (humidity ≤65%).
Shelf life: 36 months in original packaging.
| Test Item | Standard | Method |
|---|---|---|
| Assay | ≥98.0% | HPLC |
| Heavy Metals (Pb) | ≤5 ppm | AAS |
| Trimethylamine Residue | ≤50 ppm | GC-MS |
| Residue on Ignition | ≤0.1% | Muffle Furnace |
De Heus Group (Netherlands):
"Adding 0.1% choline chloride to broiler feed reduced FCR from 1.75 to 1.62, saving €12.8/MT feed cost."Shouguang Vegetable Base (China):
"0.3% foliar spray during tomato ripening decreased fruit cracking by 28% and increased single-fruit weight by 22%."Sun Pharma (India):
"Adjuvant therapy for fatty liver showed 41% higher efficacy vs. monotherapy (P<0.01)."
As a methyl donor and phospholipid synthesis catalyst, choline chloride delivers:
Livestock: ¥35 extra profit per market hog
Agriculture: ¥500+/mu added value for cash crops
Pharma: 40% lower treatment cost for liver diseases
With China supplying 56% of global capacity, supply chain stability reaches 99.7%.
Q1: Is Choline Chloride safe for animal feed use?
A1: Yes, Choline Chloride is safe and widely used in animal feed formulations to promote growth, health, and productivity.
Q2: Can Choline Chloride be used in human medicine?
A2: Yes, it is used in treating fatty liver and cirrhosis by supporting lipid metabolism and aiding acetylcholine synthesis.
Q3: How is Choline Chloride applied in agriculture?
A3: It is sprayed during crop growth stages to enhance photosynthesis and yield.
Q4: What storage precautions are necessary?
A4: Store in a dry, sealed environment at room temperature to prevent deliquescence. Dehumidifiers are recommended for long-term storage.
Q5: Where can I find more details about related chemicals?
A5: Visit JIANGYIN TRUST INTERNATIONAL's product page for additional information.
For comprehensive solutions, JIANGYIN TRUST INTERNATIONAL ensures quality and consistency in every product we deliver.
