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L-Glutathione Reduced CAS 70-18-8

L-Glutathione Reduced detoxifies acrylonitrile, fluoride, carbon monoxide, heavy metals, and organic solvents. It protects the erythrocyte membrane, prevents hemolysis, and reduces methemoglobin. It alleviates symptoms from radiation therapy and radiopharmaceuticals, and reduces bone marrow inflammation. The product inhibits fatty liver and improves symptoms of toxic and infectious hepatitis. It can also anti-allergy, restore acetylcholine and cholinesterase balance, and prevent skin pigmentation. It inhibits cataract formation and controls corneal and retinal disease development.
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Product Description


This product is an endogenous non-protein thiol bioactive substance, with the chemical name 5-L-glutamyl-L-cysteinylglycine (commonly known as Glutathione, Reduced Form). It has a CAS number of 70-18-8, a molecular formula of C₁₀H₁₇N₃O₆S, and a molecular weight of 307.323.
In appearance, it presents as a white crystalline powder with no peculiar odor and excellent solubility. It dissolves easily in water (solubility up to 50mg/mL), dilute alcohols, liquid ammonia, and N,N-dimethylformamide (DMF), but is insoluble in organic solvents such as ethanol, ether, and acetone. This property gives it a natural advantage in applications involving aqueous systems. 
From a molecular structure perspective, the thiol group (-SH) contained in this product is the core active group. It also has 2 confirmed atomic stereocenters, with 6 hydrogen bond donors and 8 hydrogen bond acceptors. Its unique structure endows it with excellent biocompatibility and physiological activity. As a substance that can be naturally synthesized by the human body, it can also exert multiple functions through exogenous supplementation, making it widely applicable in fields such as medical health and cosmetics.


Product Advantages

Endogenous Nature with High Safety and Compatibility


As a naturally occurring antioxidant in human cells, this product has far better compatibility with biological tissues than synthetic antioxidants, eliminating concerns about rejection or adaptation issues caused by exogenous substances. Toxicological tests show that the oral LD₅₀ in mice reaches 5000mg/kg, the intraperitoneal LD₅₀ is 4020mg/kg, and its acute toxicity is classified as mild (Category 5). Additionally, it has no confirmed carcinogenicity (not listed as a human carcinogen by IARC), resulting in extremely low risks in daily use and medical applications.


Multi-Functional Synergy with Wide Application Coverage


Unlike bio-reagents with single functions, this product integrates "antioxidation, detoxification, metabolic regulation, and tissue protection" in one. It can scavenge oxygen free radicals to alleviate oxidative stress, bind toxic substances (e.g., heavy metals, carbon monoxide) to promote their excretion, and assist in liver metabolism and skin condition improvement. It can be applied across multiple fields including medicine, cosmetics, and scientific research, eliminating the need for separate product adaptation for different needs.

Strong Stability with Convenient Storage and Use

Under sealed conditions, this product can be stored for a long time in a cool, dry environment at 4°C (or 2-8°C) without easy decomposition. It only needs to be kept away from strong oxidizing agents, and no special strict protective equipment is required for daily operations (basic goggles and nitrile gloves are sufficient). After dissolution, it easily integrates with other systems, reducing operational complexity in both laboratory research and industrial production.

Product Characteristics

Distinct Physicochemical Properties with Controllable Parameters

This product has a density of 1.4±0.1 g/cm³, a melting point range of 182-192°C (decomposition temperature, maintaining structural stability when heated), a boiling point of up to 754.5±60.0°C (under 760mmHg), and a flash point of 410.1±32.9°C. It is not easily flammable in high-temperature environments, further enhancing safety during use. With a LogP value of -0.87 and a polar surface area (PSA) of 197.62000, it can disperse quickly in aqueous systems without the need for additional solubilizers.

Outstanding Bioactivity with Clear Physiological Functions

As an endogenous antioxidant, the core function of this product is to scavenge oxygen-derived free radicals in the body, serving as a key marker for measuring "oxidative stress levels". Meanwhile, it acts as a coenzyme/cofactor for glyceraldehyde-3-phosphate dehydrogenase and glyoxalase, participating in the tricarboxylic acid cycle and glucose metabolism to supply energy to cells. It can also activate thiol enzymes (e.g., cholinesterase) and regulate acetylcholine balance, achieving multi-effect regulation at the physiological mechanism level.

Controllable Quality with Strong Compliance

This product meets relevant chemical product standards and can provide Chinese and US versions of Material Safety Data Sheets (MSDS). Its HS code is 2930909090, classified as "other organic sulfur compounds". The import and export process is clear (value-added tax rate of 17.0%, tax rebate rate of 13.0%), and there are clear quality control standards for production and circulation, making it suitable for large-scale industrial applications and scientific research scenarios.

Product Applications

Medical and Health Field

     Liver Protection: As a key regulatory substance for liver metabolism, it can assist in the treatment of various liver diseases, promote hepatocyte repair, improve liver detoxification function, and alleviate chemical liver injury.  
     Adjuvant Cancer Therapy: Supplementary use during chemotherapy and radiotherapy can reduce the damage of radiation and chemotherapeutic drugs to normal cells, mitigate side effects such as nausea, vomiting, and myelosuppression, and improve patients' treatment tolerance.  
     Toxicity Treatment: It can bind to acrylonitrile, fluoride, carbon monoxide, and heavy metal ions (e.g., lead, mercury) to form non-toxic or low-toxic complexes that are excreted from the body, serving as an important auxiliary component in the treatment of poisoning caused by the above substances.  
     Ophthalmic Care: For cataracts, this product can improve the oxidative environment of the lens, delay the progression of lens opacification, and is widely used as an auxiliary therapeutic component for ophthalmic diseases.

Cosmetics and Skincare Field 

This product can inhibit the production and deposition of melanin in the skin, reducing the formation of pigment spots. At the same time, it scavenges oxygen free radicals in skin cells, delays collagen loss, improves skin aging issues such as sagging and dryness, and enhances the skin's antioxidant capacity and radiance. It is commonly used as an anti-aging and whitening active ingredient in high-end skincare products.

Scientific Research and Potential Applications

In life science research, this product is an important biochemical reagent for studying oxidative stress and cell metabolism, widely used in experiments in fields such as cardiovascular diseases, inflammatory immunity, and neurological diseases. Recent studies have shown that it may also have the potential to inhibit the AIDS virus, providing a new direction for research and development in the antiviral field.

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JIANGYIN TRUST INTERNATIONAL INC was established in 1996, dedicated to the production and export of water treatment chemicals, intermediates, and other chemicals. 

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